Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

The best scientist is open to experience and begins with romance-the idea that anything is possible. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.tribution and levels of cathepsinD and cystatins in amyotro-phic lateral sclerosis transgenic mice: Possible roles in motor neuron survival. Reprints were made with permission from the publishers. Abbreviations ALS Amyotrophic lateral sclerosis AD Autosomal dominant AR Autosomal recessive BIP Binding protein CathB Cathepsin B CathD Cathepsin D CathL Cathepsin L CHOP C/EBP homologous protein CNS Central nervous system COX2 Cyclooxygenase 2 CSF Cerebral spinal fluid CystB Cystatin B CystC Cystatin C DNA Deoxyribonucleic acid ER Endoplasmic reticulum FALS Familial ALS GFAP Glial fibrillary acid protein IAP Inhibitor of apoptosis protein IHC Immunohistochemistry IL-6 Interleukin 6 IPC Insoluble protein complexes m Mouse MN Motor neuron PCR Polymerase chain reaction rb Rabbit RING Really interested new gene (= protein name) RNA Ribonucleic acid ROS Reactive oxygen species SOD1 Super oxide dismutase (the gene) SOD1 Super oxide dismutase (the protein) SALS Sporadic ALS TNF-Į Tumor necrosis factor Į WB Western blot XIAP X-linked inhibitor of apoptosis protein 11 Introduction